Gareth Bale's injury woes may be set to continue as the Real Madrid star was withdrawn at the half in his side's scoreless draw with Atletico.
But held off the scoresheet in a disappointing 3-0 loss to Sevilla midweek, Bale looked to get back among the goals in the big clash against their local rivals.
Yet his match would be ended early as though he made it through the first 45, Dani Ceballos came on to replace him at the start of the half.
Goal can confirm Bale has an adductor injury in his leg, though the severity of the problem is yet to be determined.
Injuries have been a problem for Bale for much of his Real Madrid career with calf and thigh problems costing him most of October and November of last season, though he did manage to make 26 league appearances last year and went as an unused substitute in seven other La Liga contests.
Other sets of injuries limited him to just 19 league appearances in 2016-17 and 23 in La Liga the year before.
"It's not good at all so many injuries (Bale, Isco, Marcelo)," Real boss Julen Lopetegui said after confirming that Bale was taken off with a knock and would have medical tests on Sunday.
"What the coaches have to do is to look for solutions. And trust on our squad until death. Just look how Ceballos played today. He was fantastic"
Madrid then return to action October 20 against Levante.