This fixture has become one of the biggest games in Europe over the last few years with these two sides meeting in various competitions.
As well as in La Liga, over the last five years Atletico Madrid and Barcelona have met in the latter stages of the Copa del Rey and the Champions League, as well as contesting the Spanish Super Cup.
None of the last 17 meetings have ended goalless and Saturday's league clash at the Estadio Wanda Metropolitano should once more see goals.
Latest odds
Lionel Messi returned from injury just before the international break scoring two goals in Barca's 4-3 home defeat at the hands of Real Betis.
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The Argentine sits top of the La Liga scoring charts alongside team-mate Luis Suarez with both men having netted nine goals this term.
Messi is offered at 7/2 (4.50) to break the deadlock and at 11/10 (2.10) to score at anytime. Suarez meanwhile can be backed at 13/10 (2.30) to score, while Atleti's Antoine Griezmann is offered at the same price.
Messi to overshadow Costa
During his career Messi has netted 28 goals against Atletico in all competitions, making them his second favourite opponent after Sevilla.
His impressive strike-rate in this fixture is in stark contrast to that of Diego Costa's who has failed to find the back of the net in any of the nine matches he has played against Barcelona.
The Spain international striker is on a particularly poor run of scoring form having failed to net a league goal since February 25 and the price of 23/10 (3.30) for him to score on Saturday does not overly appeal.
Tips and predictions
Messi to score at anytime, Barca to win and both teams to score is priced at 6/1 (7.00) and looks like and excellent value option for this game.
Indeed this selection has paid out in two of Barca's last three away games against Atletico in all competitions and is offered at a healthy price.
Messi to score, Barcelona to win and both teams to score at 6/1 (7.00) for a 1pt stake with William Hill
William Hill
