The Basques are the only other side in La Liga not to have lost a game at home this season, although Alaves have been considerably weaker on the road, losing three of their last four away matches.
Atletico have lost just one of their last 28 La Liga matches at home and William Hill price them at 7/20 (1.35) to record a win.
Diego Costa is facing a lengthy spell on the sidelines after underdoing surgery on a foot injury and left-back Filipe Luis will miss out once again, with midfielder Saul Niguez filling in.
Captain Diego Godin has not played in the last four matches with a muscle injury, meaning the centre-back pairing for Los Rojiblancos could once more be Stefan Savic and Jose-Maria Gimenez.
Alaves remain without centre-back Rodrigo Ely who is a long term absentee.
With Atletico extremely strong at home and Alaves poor on the road, all indicators point towards a victory for Diego Simeone's men.
If we think Atletico are likely to win then there has to be a case made for backing them to keep a clean sheet as well, as they have done in each of their last three matches against Alaves.
In fact, in 18 of their last 21 home league wins, Atletico have been the only team to score and there is every reason for us to think this will happen once more against a team with a poor away record.
Tips and predictions
Atletico Madrid to win to nil is offered at 3/4 (1.75) and that price is big enough for us to consider, given how regularly it has paid out in La Liga clashes at the Wanda Metropolitano.