Diego Simeone has built a side that knows how to battle and despite playing with ten men for 80 minutes, Los Rojiblancos scraped a 1-1 draw at the Emirates that puts them in a strong position to make it through to the final.
The major factor in Atleti's favour is just how solid they are defensively at the Wanda Metropolitano, where only nine goals have been scored by the opposition in 26 matches this season.
Atletico have right-back Sime Vrsaljko suspended after his red card in the first leg and with fellow right-back Juanfran injured, Simeone may have to reshuffle things at the back.
Diego Costa should return after missing last week's game in London through injury, and Filipe Luis has been included in the squad after almost two months out with a broken leg.
The Gunners are hoping to have Henrikh Mkhitaryan available after the Armenian made his comeback from injury at the weekend, only to be taken off in the game at Old Trafford after picking up a knock.
Tough task for Arsenal at the Wanda Metropolitano
Arsenal know they must score to have any hope of progressing but will certainly have their work cut out against a side that has kept 11 consecutive clean sheets at home.
Jan Oblak's display in the first leg went some way to explaining that record, with the Slovenian showing why he is considered by many to be the best goalkeeper in Europe.
Scoring at the Wanda Metropolitano is not impossible for Arsenal, yet it is no doubt a tall order, and backing a low-scoring contest once more must surely be the angle for this game.