The England international has hit the net seven times in seven league matches against the local rivals, failing to fire in just one of those encounters.
With six goals to his name in his last eight appearances for club and country, the star striker is priced at just 17/20 (1.85) anytime odds to fire past the Gunners once again.
However, considering Unai Emery’s men have scored three quarters of their league goals after half-time this season, 10/3 (4.33) could prove a smart bet on Kane grabbing the opener on enemy turf.
Son Heung-Min scored probably the most spectacular of Tottenham’s three goals in that victory, and is on offer at 2/1 (3.00) to make more headlines by finding the net once again.
At the other end of the pitch, the visiting defence cannot afford any space to Pierre-Emerick Aubameyang, who has scored a league-high eight goals from just his last eight shots on target.
Aubameyang is not the only danger man though, with Alexandre Lacazette a 21/20 (2.05) shot to add to his tally of five goals in nine league starts this campaign.
Mesut Ozil did not even make it off the bench in last weekend’s victory over Bournemouth, but can be backed at 23/10 (3.30) to prove his worth with a big goal in this one.