The Gunners are currently level on points with Chelsea and one point adrift of fourth-placed Manchester United, with the former not in league action this weekend and the latter facing a tough game against Liverpool.
Having won 10 and lost none of their last 12 league matches in front of their own fans, they are priced at 1/2 (1.50) with SportPesa to come out on top here.
However, Ralph Hasenhuttl’s men ran out 3-2 winners in December’s reverse encounter, and can be backed at 11/2 (6.50) to complete the league double over this opposition for the first time since the 1987-88 season.
Just one of the last seven encounters between this pair has resulted in a draw, but there are odds of 33/10 (4.30) available on this one finishing all square.
Ainsley Maitland-Niles will face a late fitness test after missing the BATE clash due to illness, while Laurent Koscielny is also a doubt after coming off injured in that game.
Stuart Armstrong, Mario Lemina and Michael Obafemi could all be in contention following injury, although Danny Ings remains sidelined.
Koscielny’s withdrawal will cause a serious headache for Unai Emery, whose defensive options have been limited by injuries to Hector Bellerin, Rob Holding, and Stavros Mavropanos.
With just three clean sheets to their name, his side are unlikely to look too solid against a Saints team that scored three goals the last time they met – and have failed to find the net just twice in 15 fixtures.
Nevertheless, Arsenal’s strong form at the Emirates and record of 15 wins and no defeats in 19 home games against Southampton make odds of 9/5 (2.80) a strong bet on them winning despite conceding.