That defeat was Arsenal's fifth in their last 10 matches in all competitions and they will need to improve if they want to secure a positive result at home on Thursday.
A chasm of 27 points separates City in first from Arsenal in sixth and the Gunners, who are also 10 points adrift of fourth-place Tottenham, will be hoping to reclaim some pride at the Etihad.
|Game||Arsenal vs Manchester City|
|Date||Thursday March 1|
|Time||19:45 GMT / 14:45 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Goalkeepers||Ospina, Cech, Macey|
|Defenders||Mertesacker, Koscielny, Holding, Monreal, Mustafi, Chambers, Bellerin, Kolasinac, Mavropanos, Osei-Tutu|
|Midfielders||Mkhitaryan, Ramsey, Wilshere, Ozil, Iwobi, Xhaka, Maitland-Niles, Elneny, Dragomir, Gilmour, Willock|
|Forwards||Aubameyang, Welbeck, Dasilva, Nelson, Nketiah|
Alexandre Lacazette recently underwent surgery on a knee injury so he is definitely out and Santi Cazorla is a long-term absentee who has been troubled by an ankle complaint.
Nacho Monreal has been ruled out for the next few games too after suffering an inflamed disc in his back, but the remainder of the squad are fit to play.
Potential Arsenal starting XI: Cech; Kolasinac, Koscielny, Mustafi, Bellerin; Wilshere, Xhaka, Ozil, Mkhitaryan, Ramsey; Aubameyang.
|Position||Man City players|
|Goalkeepers||Bravo, Ederson, Grimshaw|
|Defenders||Walker, Danilo, Kompany, Stones, Laporte, Adarabioyo, Otamendi, Duhaney|
|Midfielders||Sterling, Gundogan, De Bruyne, Sane, B. Silva, D. Silva, Fernandinho, Zinchenko, Toure, Foden, Diaz, Dele-Bashiru|
|Forwards||Aguero, Nmecha, Jesus|
Fernandinho is definitely out of the game after suffering a hamstring injury on Sunday, but Raheem Sterling could be available again after Guardiola revealed he is "much, much better".
Brazil international Gabriel Jesus is back in contention after making a substitute appearance in the final.
Potential Man City starting XI: Ederson; Walker, Otamendi, Kompany, Danilo; Gundogan, D. Silva, De Bruyne; Sane, Aguero, Jesus.
Betting & Match Odds
Man City are, perhaps unsurprisingly, favourites to win with dabblebet giving odds of 3/4 on Guardiola's men. Arsenal are deemed a 7/2 bet to win and a draw is available at 3/1.
Icy conditions are enveloping the United Kingdom this week as the so-called 'Beast from the East' arrives and the Emirates Stadium is becoming an increasingly cold house for Wenger too.
The Arsenal boss was denied a maiden League Cup trophy on Sunday after his side meekly succumbed to the might of Guardiola's City and the question of his future has now arisen once more.
Even if the veteran coach guides the Gunners to a win over City on Thursday, those questions won't go away, but he will be able to use a victory as a springboard for a strong finish to the season.
City, on the other hand, are incredibly secure at the top of the table and have now comfortably beaten the Gunners twice this season.