Arsene Wenger's side have won each of their last three matches - scoring eight goals and conceding just once - and will be confident of chalking up a fourth successive win on Sunday afternoon.
The Gunners are bet365's 1/3 (1.34) favourites to pick up all three points in north London.
Stoke find themselves in the bottom three with just eight matches to go and they have not won since January in Paul Lambert's first match in charge of the Potters.
Furthermore, Stoke have won just one of their 15 Premier League matches away from home this season.
Stoke midfielder Charlie Adam is suspended after being sent off in the 2-1 defeat against Everton last time out, but Mame Biram Diouf and Stephen Ireland could return.
Laurent Koscielny, Jack Wilshere and Alexandre Lacazette are all expected to be available for selection, while Aaron Ramsey is also back in training despite missing out on both of Wales' China Cup ties during the international break.
There have been at least three goals scored in each of Arsenal's last 10 home matches, and bet365 go 1/2 (1.50) that the trend continues in this clash.
The same firm also offer 6/5 (2.20) that there are four or more goals in the game, a selection which would have landed in two of the last three meetings between the sides.
Tips and predictions
Stoke's record on the road is a cause for concern, while the Gunners have been in the groove in recent weeks.
bet365 go 5/6 (1.83) that Arsenal win by at least two clear goals in this game and that could provide punters with a path to profit, for it would have landed in each of the last five fixtures that Wenger's men have won.
Odds correct at time of writing. Please gamble responsibly.