Arsene Wenger's men already have one foot in the next round after securing an impressive 2-0 away victory at the San Siro in the first leg.
Having followed that up with a convincing 3-0 league victory over Watford at the weekend, they are even odds (2.00) favourites with dabblebet to add to their aggregate advantage by coming out on top once again.
Last week's defeat was the only one the Rossoneri have suffered in 15 matches, and they are available at 5/2 (3.50) to keep their chances of progression alive with a victory here.
The hosts have drawn just one of their matches in this season's competition, but you can get odds of 12/5 (3.40) on them easing into the next round with a stalemate in this one.
Hector Bellerin and Nacho Monreal have both returned to training after missing the last two matches, as has Shkrodan Mustafi after sustaining groin injury against Watford.
Pierre-Emerick Aubameyang and Alexandre Lacazette's unavailability means Danny Welbeck will once again lead the line.
Andrea Conti and Ignazio Abate remain the only players unavailable for Gennaro Gattuso, who is expected to field the same line-up as in the home leg.
This was underlined with last week's impressive away win, and there seems little chance of them displaying the type of complacency that saw follow up an away victory over Ostersunds with an embarrassing home defeat.
After recording consecutive clean sheets for the first time since December, Arsenal are likely to keep things tight and strive to protect their lead in this clash.
Preview and predictions
Having conceded just five goals in 15 matches but scored only 20 at the other end of the pitch in that time, the Italians look set to help ensure a tense and competitive clash.
No more than two goals can be backed at a generous even odds (2.00), and is good value to pay out for Milan's seventh match in a row.