Currently fourth in the league after winning five of their last six fixtures, Arsene Wenger's men are available at 6/4 (2.50) with dabblebet to ramp up the pressure on their second-placed opponents with a 12th consecutive victory on home turf.
However, no team has won more away matches against Saturday's hosts than the Red Devils, who are priced at 15/8 (2.88) to collect maximum points for a record eighth occasion in North London.
Just one of the home team's last 25 league matches has resulted in a draw, but you can get odds of 12/5 (3.40) on them being forced to settle for a single point in this one.
Although the accusation clearly rankles with him, there is no doubt that Jose Mourinho takes a conservative tactical approach to high profile matches.
With the focus on avoiding defeat rather than chasing victory, the Portuguese manager has seen his side score once and concede just once in three matches against Liverpool, Tottenham and Chelsea so far this campaign.
In total, his record since arriving at Old Trafford reads 13 goals against and just eight scored in 13 matches against the rest of the top six, with 10 of those 13 fixtures producing no more than two goals.
Considering the Gunners' strong home form, it is unlikely that the former Chelsea boss will take any chances by deviating from this game plan in this clash.
Having kept nine clean sheets in their 12-match winning streak in their own back yard, Arsenal look every bit as capable of ensuring this clash is a tight and tense affair.
All in all, odds of 5/6 (1.83) appear generous on under 2.5 goals being scored for third encounter in a row between these teams.