Widely criticised for his lack of impact in games against Liverpool, Tottenham and Chelsea this season, the Belgian striker is priced at 9/2 (5.50) with Paddy Power to hit back at the doubters by opening the scoring in North London.
However, the 24-year-old is not in strong form after finding the net just once in his last 11 club appearances, making 17/10 (2.70) anytime odds look perhaps rather unappealing as he faces a defence that has kept nine clean sheets in 12 league matches at home.
Indeed, the Red Devils have failed to score in three of their last four visits to this ground, so they will need everyone firing on all cylinders in order to make a breakthrough this time out.
On target in three of his last five league games, Anthony Martial is available at 11/4 (3.75) to offer the same cutting edge he provided by scoring the winner against Tottenham recently.
Meanwhile, Marcus Rashford made his name with two debut goals against Arsene Wenger's team in February 2016 and can be backed at 11/4 (3.75) to grab the headlines once again.
Realistically, the most likely goal-scoring candidates appear to found at the other end of the pitch, where the Gunners have averaged almost three goals a game in front of their own fans.
Alexis Sanchez looks like the best value 9/2 (5.50) first goalscorer bet after getting on the scoresheet in each of his last three appearances, while 17/10 (2.70) anytime odds certainly appear generous.
Similarly, Olivier Giroud is sure to attract plenty of attention at 15/8 (2.88) after scoring twice in Wednesday’s 5-0 win over Huddersfield, while Mesut Ozil is a potentially lucrative longer shot at 7/2 (4.50) considering he has struck in two of the last four encounters between the teams.