The 68-year-old has been Arsenal manager for almost 22 years and it is set to be an emotional occasion when Wenger's men go toe-to-toe with Sean Dyche's Clarets.
Arsenal are chalked up as an 8/15 (1.53) chance to take all three points and guarantee a top-six finish for the Gunners, while bet365 go 3/1 (4.0) that Wenger's final home fixture here ends in stalemate.
Burnley have enjoyed a magnificent campaign and they are on the brink of qualifying for European competition for the first time in 50 years.
The Clarets, though, have won just one of their 11 matches against Arsenal during Wenger's time in north London, and bet365 go 5/1 (6.0) that the Clarets claim all three points on this occasion.
Scott Arfield, Robbie Brady, Steven Defour, Jonathan Walters and Ben Mee are out, while Dyche will decide whether to field fit-again Tom Heaton or continue with Nick Pope in goal.
Wenger must choose whether to name his strongest side or give another chance to the fringe players who impressed in a 2-1 defeat against Manchester United at Old Trafford last weekend.
Nevertheless, captain Laurent Koscienly will join Santi Cazorla and Mohamed Elneny on the sidelines after sustaining a torn achilles against Atletico Madrid on Thursday.
A final home win for Wenger?
Arsenal have won six of their last seven home matches in all competitions at Emirates Stadium and the Gunners are capable of maintaining their strong home form with a win in this one.
Burnley have won just three of their last 12 matches on the road, while the Clarets have been beaten in their last seven matches against Arsenal in all competitions.
Each of Arsenal's last five wins against Dyche's side have been by a single goal margin and bet365 go 13/5 (3.60) that the Gunners again win by just one goal on this occasion.
Tips and predictions
Arsenal have kept just two clean sheets in their last 14 home fixtures, but they boast plenty of quality in the final third, having scored 21 goals in their last seven matches on their own patch.
There is plenty of potential for goals, then, and so it is bet365's 4/5 (1.80) quote for both teams to score that could represent good value ahead of Sunday's showdown.
Odds correct at the time of writing. Please gamble responsibly.