Petr Cech misses out with a groin problem meaning Matt Macey takes his place on the bench, while Laurent Koscielny, Sead Kolasinac and Granit Xhaka are among the substitutes.
Mohamed Elneny starts in defensive midfield a week after signing his new contract extension with the Gunners and sits alongside Jack Wilshere and Aaron Ramsey.
Meanwhile, Stoke hand a start to Mame Biram Diouf following his return from injury with Swiss star Xherdan Shaqiri also starting in attack.
Arsenal XI: Ospina, Bellerin, Chambers, Mustafi, Monreal, Elneny, Wilshere, Ramsey, Ozil, Welbeck, Aubameyang
Subs: Macey, Koscielny, Kolasinac, Xhaka, Iwobi, Mkhitaryan, Lacazette
Stoke XI: Butland; Johnson, Shawcross, Martins Indi, Pieters; Bauer, Badou, Allen; Ramadan, Diouf, Shaqiri.
Subs: Haugaard; Ireland, Berahino, Cameron, Crouch, Campbell, Sorense