Arsenal showed that they mean business with an impressive 4-2 victory over Tottenham in the north London derby on Sunday.
The Gunners brushed aside Mauricio Pochettino's men after a second-half performance which saw Pierre-Emerick Aubameyang become the Premier League's top scorer, while Alexandre Lacazette and Lucas Torreira also got in on the act.
Unai Emery's side are now 19 games unbeaten in all competitions and continue to look like a force worthy of top-four contention, although the former Sevilla boss will come up against Jose Mourinho on Wednesday night as Arsenal face Manchester United. Mourinho has not lost in his five previous meetings with Arsenal's head coach.
Mesut Ozil is being assessed ahead of the game after being ruled out of the victory over Spurs due to a back problem.
Danny Welbeck is ruled out with a broken ankle following his shocking injury against Sporting CP , while Nacho Monreal is sidelined with a hamstring injury.
Dinos Mavropanos faces further time out on the sidelines with a groin injury, but is expected to return to training at some point in December, with Laurent Koscielny back in contention after his long-term Achilles issue.
Arsenal have Granit Xhaka suspended for the game at Old Trafford due to collecting five yellow cards so far this season.
Possible Arsenal Starting Line-Up
Emery is expected to stick with Sead Kolasinac at left-back following Monreal's injury, with Ozil still a doubt due to back problems.
Henrikh Mkhitaryan, on his return to Old Trafford, could start again after being taken off at half-time against Tottenham, although Aaron Ramsey is also an option after his impressive cameo against Mauricio Pochettino's side.
Matteo Guendouzi and Lucas Torreira are expected to anchor the midfield, but Emery may decide to return to four at the back with Sokratis and Rob Holding partnering each other.
Man United Team News
Jose Mourinho is expected to make at least one change to United's starting XI on Wednesday night. Ashley Young is suspended after receiving his fifth yellow card of the season in Saturday's 2-2 draw with Southampton, which means youngster Diogo Dalot could start in his place at Old Trafford.
Luke Shaw is a doubt after being replaced against the Saints due to a knock, while Chris Smalling and Eric Bailly are also doubts.
Alexis Sanchez will miss out against his former club after he suffered a hamstring injury in training last Thursday.
TV Coverage & Kick-Off Time
Kick-off is 8pm GMT (3pm ET) on Wednesday, and the game will be broadcast live on Sky Sports in the United Kingdom. It will be shown on NBCSN in the United States, and on various channels around the world.
Best Opta Match Facts
Manchester United are unbeaten in their last 11 home Premier League games against Arsenal (W8 D3), since a 0-1 loss in September 2006.
This is the first time Man Utd have hosted Arsenal in a midweek Premier League match since May 8th 2002, when Arsenal won 1-0 to clinch the title thanks to a Sylvain Wiltord strike.
Arsenal are unbeaten in their last 19 games in all competitions. They last went 20 without defeat between April/November 2007 (28 games).
Man Utd boss Jose Mourinho has never previously lost in five meetings with Arsenal manager Unai Emery (W4 D1, all in La Liga), with this their first meeting since October 2013 (Mourinho’s Real Madrid beating Emery’s Sevilla 4-1).
Arsenal’s Pierre-Emerick Aubameyang has scored with each of his last 10 shots on target in the Premier League.