The draw ceremony was held in Nyon, and saw Oshoala and her Spanish champions drawn against the Eredivisie Vrouwen giants, who were appearing at the stage for the first time in their history.
Having failed to earn back-to-back Champions League final berths last season, the Nigeria star will be hoping to inspire her side's return to title reckoning this term, but they must see off the Dutch champions.
Nigeria-born Swedish youth international Evelyn Ijeh will be eyeing a Round of 16 spot with Swedish champions Kopparbergs/Goteborg against English giants Manchester City.
Also, Algeria's Imane Chebel and Zambia's Racheal Kundanaji will be in action as Kazakhstani winners BIIK Kazygurt were pitted against Ukrainian champions Zhytlobud-2 Kharkiv.
As for Cameroon's Ajara Nchout, her Norwegian side Valerenga are billed to challenge for a place in the next round with Danish giants Brondby.
Cameroon duo of Henriette Akaba and Alvine Njolle alongside Cote d'Ivoire's Nadege Cisse will seek to help Minsk pip Norwegian side Lillestrom to book a Round of 16 place.
The Round of 32 first legs will be played on December 9-10 and the second legs on December 15-16 across 16 venues in Europe.