The Pharaoh have made their intentions very clear by dominating a group with victories over Uganda, Zimbabwe and DR Congo.
Javier Aguirre is under pressure to deliver a record-extending Afcon title with the North Africans.
The Mexican coach will face South Africa who scraped into the knockout phase as one of the four best third-placed teams having finished third in Group D.
Bafana Bafana struggled during their group stage campaign as they registered defeats against Morocco and Ivory Coat, but a narrow win over Namibia was enough to take them to the next round.
Coach Stuart Baxter is looking to produce an improved performance with his side having been slammed for their lacklustre displays in the group stage.
|Game||Egypt v South Africa|
|Date||Saturday, July 6|
|Time||21:00 pm SA Time|
TV Channel, Live Stream & How To Watch
In South Africa, the game will be shown live on SuperSport TV and SABC
|DSTV channel||Free-to-air channel|
|SuperSport 4||SABC 3|
Squads & Team News
Egypt's influential forward Mohamed Salah missed training with a cold on Thursday, but he is expected to be fit to face South Africa.
The Liverpool FC star and Egypt teammate Mahmoud 'Trezeguet' Hassan have established themselves as the Pharaohs' key players, having scored three goals between them in the tournament.
Aguirre will look to the two attackers, who have the ability to inspire Egypt to victory over an unpredictable South Africa side.
Probable Egypt line-up: El Shenawy, Elmohamady, Hegazy, Alaa, Ashraf, Elneny, Hamed, Salah, Elsaid, Trezeguet, Mohsen.
South Africa will have to do without their key attacker Themba Zwane, who will miss the clash against the tournament hosts due to suspension, having picked up two yellow cards in the group stage.
Baxter had indicted he will replace the Mamelodi Sundowns player with either Lebohang Maboe or Thembinkosi Lorch in the starting line-up.
However, the British trainer will once again look to Brighton and Hove Albion forward Percy Tau, who is yet to score in the tournament, but grabbed an assist against Namibia.
Probable South Africa line-up: Williams, Mkhize, Hlatshwayo, Mkhwanazi, Hlanti, Zungu, Mokotjo, Serero, Maboe, Tau, Mothiba.
In Head-to-Head stats, Egypt and South Africa have locked horns 11 times.
Bafana have recorded six victories compared to the Pharaohs' four victories, while one match ended in a draw.
The last time the two teams met in an Afcon tournament, Egypt won 2-0 to clinch the 1998 title in the final.
However, South Africa are undefeated in their last three matches against Egypt.