The match will be United's third pre-season fixture on American soil following back-to-back draws against Club America and San Jose Earthquakes respectively.
Milan will play in European competition this term after seeing a ban overturned by the Court of Arbitration for Sport last week and, so, Gennaro Gattuso's men will be in good spirits.
Alexis Sanchez is likely to continue in attack with Romelu Lukaku enjoying a break after scoring four World Cup goals for Belgium.
Ivan Strinic, Lucas Biglia, Andrea Conti, Riccardo Montolivo and Carlos Bacca are amongst the absentees from Gattuso's squad.
There were eight goals scored in Milan's two appearances in this competition last term and SportPesa offer 20/31 (1.65) that there are more than two goals in this game.
The same firm offer 4/7 (1.57) that both teams are on target here, as has been the case in seven of United's 12 total games in this tournament.
United could be slightly sharper than the Serie A side, having already played two warm-up matches on US soil and SportPesa's 29/20 (2.45) quote for Mourinho's men to win on Wednesday night could represent decent value.