By Andrew Southwick
The visitors will once again come armoured with a makeshift back four, with three of his first-choice back four missing.
Hodgson knows his side must exploit that weakness if they are to be victorious.
"At the moment they are weaker than when we played them last year because they don't have Neville, Ferdinand and Vidic playing for them," he told the Press Association.
"They don't even have the players that Sir Alex would like to replace them with like (Wes) Brown, (John) O'Shea and Jonny Evans so that's the obvious weakness.
"Sir Alex has great qualities, I could sit here and talk about him all afternoon.
"I have known him for a long time and there is nothing but praise you can shower upon him. They deserve the utmost respect and that's what we will give them tomorrow."
Manchester United had Wayne Rooney and Paul Scholes sent off in a 2-0 win for Fulham last season, and Hodgson would love to repeat that.
One man who could be a match winner for the home side is on form Bobby Zamora.
"I think the things he did last season - the movements, the team-work, his dedication to the team and his unselfish behaviour for the team are unchanged," Hodgson said.
"He was getting into positions but unfortunately the ball wasn't falling to him, but this year has.
"I remember saying to him at the start of this season, 'You will score goals because you are a good player and you have the technique to score goals'.
"He had a barren year but luckily this year it's more normal. He's not doing exceptional for him, but that's what he should be doing.
"We are just fortunate in the barren year it was still a good year for us because he helped us achieve our best ever result."