The pair played together at Sampdoria, but the relationship broke down when Icardi started seeing the model soon after she split with Lopez.
But Icardi, now leading the line at Inter, is adamant that the marriage was already over when he got together with Wanda.
"Everyone speaks about the Wanda issue without knowing the truth. When I started with her I played alongside Diego Milito, [Javier] Zanetti, [Esteban] Cambiasso, [Walter] Samuel, and they all knew the story because I told them," he fired to Fox Sports.
"I was a friend of the couple, an acquaintance, and it was all very normal. After that, Wanda split up and we kept in contact, and it just happened.
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"I fell in love, that's something you should judge solely on its own merits. But [Lopez] was not my best friend, nothing like that. We were colleagues in Sampdoria, nothing else."
It has been widely speculated in Argentina that the scandal has delayed Icardi's entry into the national team, after he made his debut at the end of 2013.
Gerardo Martino, however, has included the young striker for the first time in his plans as he was added to the Olympic Games shortlist for Rio 2016.
"I was a little surprised to be on the Rio list because after everything that's been said, in Twitter and social media everything comes out, some people believed I was never going to get called," he admitted.
"It is great to be on the Olympic list because it is a prize for my Inter performances.
"I can tell Martino that here in Italy I am on the front pages every Monday, but of the sports newspapers. In Argentina I am always linked to the showbusiness world. If you are a national team coach, you can only judge on what happens on the pitch."