Coach Radomir Antic has called up uncapped goalkeeper Zeljko Brkic who replaces usual back-up stopper Vladimir Disljenkovic.
"All 22 players will get a chance over the two games and we will try out different formations and strategies as we start our build-up for next year's World Cup finals in South Africa," Antic said according to Reuters.
"Northern Ireland and South Korea have very contrasting styles and the matches with them will be a good opportunity for my players to keep learning and adapt to all kinds of tactics."
Like South Korea, Serbia have qualified for the 2010 World Cup, finishing above France.
Goalkeepers: Vladimir Stojkovic (Sporting), Bojan Isailovic (Cukaricki Belgrade), Zeljko Brkic (Vojvodina Novi Sad)
Defenders: Branislav Ivanovic (Chelsea), Antonio Rukavina (Munich 1860), Nemanja Vidic (Manchester United), Neven Subotic (Borussia Dortmund), Aleksandar Lukovic (Udinese), Ivica Dragutinovic (Sevilla), Aleksandar Kolarov (Lazio)
Midfielders: Dejan Stankovic (Inter Milan), Gojko Kacar (Hertha Berlin), Nenad Milijas (Wolverhampton Wanderers), Zdravko Kuzmanovic (Vfb Stuttgart), Radosav Petrovic (Partizan Belgrade), Milos Krasic (CSKA Moscow), Zoran Tosic (Manchester United), Milos Ninkovic (Dynamo Kiev), Milan Jovanovic (Standard Liege)
Strikers: Nikola Zigic (Valencia), Marko Pantelic (Ajax Amsterdam), Danko Lazovic (PSV Eindhoven)