The Colombia international is again expected to start in between the sticks when the Gunners travel to Hull City on Tuesday for their FA Cup fifth-round replay, with Petr Cech out injured.
Wenger was impressed with his stand-in custodian's nine saves against Spurs at White Hart Lane and criticised the media for how they treated him after a Champions League mistake against Olympiacos earlier in the season.
"I believe that I told you many times in these press conferences that I rate him as a top class, world-class goalkeeper," said the Frenchman.
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"I never questioned his quality. I think he had been unfairly treated when I played him against Olympiacos and it was a shame that at the time his stats did not come out in the press and that's where I thought he got unfair treatment."
Wenger confirmed a busy fixture schedule will mean he makes changes against Hull, but has confidence in every player he has to call upon.
"We made 10 changes in the first game and I believe we will have a team with a good chance to qualify, no matter who plays. David Ospina is an example of that on Saturday.
"We will have to make changes to keep the balance right but I have same respect [for the opposition] and exact same idea that every player in my squad can play and can win the game."