The Bundesliga side hold a 3-2 lead from last month's first leg tie and they will be determined to press home that advantage.
Dieter Hecking's men boast an impressive home record, with only Bayern Munich and Borussia Dortmund having claimed competitive victories at Volkswagen Arena thus far this term.
With that in mind, it is perhaps unsurprising that the German outfit are chalked up as 20/41 (1.49) favourites with NetBet to book their place in the last eight of the competition with a win in this one.
A draw, of course, would be enough to see Wolfsburg progress to the last eight and NetBet go 33/10 (3.40) that the match ends in stalemate, while the visitors are available at 9/2 (5.50) to claim a famous win in Germany.
With five goals having been scored in the first leg, it is understandable that NetBet go just 20/33 (1.61) that more than two goals are scored when these two teams lock horns, while the same firm's 4/5 (1.80) quote for both teams to score may well prove to be popular with punters.
Gent's away form, though, is sure to be a cause for concern for manager Hein Vanhaezebrouck, for his side have been beaten in four of their last five matches on the road.
Gent, too, won just one of their three Group H fixtures away from home, while Wolfsburg were victorious in all three of their Group B matches on home turf.
Gent trailed 3-0 at one stage during last month's first leg tie in Belgium, but Vanhaezebrouck's charges managed to reduce the deficit to a single goal and give themselves an outside chance of completing a famous comeback in Germany.
However, the visitors have failed to find the net in three of their last five fixtures away from home in all competitions and they may struggle to make an impact against their well-disciplined Bundesliga opponents.
Wolfsburg have leaked just 12 goals in 13 home league matches thus far this term, while Hecking's outfit also recorded clean sheets on home soil against both CSKA Moscow and PSV respectively during the group stages.
With that in mind, NetBet's 27/20 (2.35) quote for the hosts to keep another clean sheet on home turf looks to be generous and it is, therefore, the recommended play for punters ahead of Tuesday's Champions League crunch clash.
|Wolfsburg to keep a clean sheet at 27/20 (2.35) for a 2pt stake with NetBet|