The centre-back departed the Catalans as a teenager and joined Manchester United but returned to Camp Nou in 2008 and has since developed into one of the game's finest defenders.
In that time he has lifted the Champions League on two occasions and La Liga four times, while doing battle with some of the game's finest attacking players.
"I grew up at La Masia, dreaming of playing for the first team one day so you can only imagine what it means to wear this shirt 300 times," he told Mundo Deportivo.
"Many people have been fortunate to enjoy it. And all the titles we won are very special.
"Both Barca and I have had the honour of reaching the final stages of major competitions, meeting the best teams and best players.
"There have been many but I would highlight, Drogba, Cristiano Ronaldo and Lionel Messi every day in training!"
The Catalans stand two points clear of Real Madrid in La Liga, face Athletic Bilbao in the Copa del Rey final and meet Paris Saint-Germain in the Champions League quarter-finals on Wednesday.
Pique understands that there is a lot of hard work ahead of him and his team-mates but believes a first piece of silverware in two years is within their grasp.
"We to be very close and very focused.
"I hope it's a historic season. PSG have one of the best defences in the world and can beat anyone."