Van Gaal has history on his side, as the Bavarian giants have never lost to a Romanian side in the competition.
"We are very confident, we're not even considering the possibility of losing," the coach told UEFA.com. "I think the motivation to win here comes from reaching the final last year.
"The players are accustomed to being motivated for every game so the gap between the two teams in terms of points is not an issue for me and my players.
"We have two central defenders to deal with Lacina Traore - [Martin] Demichelis and [Daniel] Van Buyten - so I'm thinking about them, not the striker.
"History is very important in football but it can always change, so we are taking nothing for granted," concluded Van Gaal.
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