Mario Balotelli has once again been excluded and both Thiago Motta and Lucio are sidelined due to suspension, but 'The Special One' is clearly looking to take a first leg advantage on home soil.
Playmaker Wesley Sneijder will play in support of an attacking trident containing Goran Pandev, Diego Milito and Samuel Eto'o. Meanwhile, Javier Zanetti and Esteban Cambiasso will protect the back four.
It is a very similar formation to the one used at Stamford Bridge in the round of 16, when the Serie A leaders defeated Chelsea 1-0.
Below are the projected line-ups for tonight's encounter, which kicks off at 20:45 CET.
Inter (4-2-1-3): Julio Cesar, Maicon, Cordoba, Samuel, Chivu; Zanetti, Cambiasso; Sneijder; Pandev, Milito, Eto'o.
CSKA Moscow (4-2-3-1): Akinfeev; A. Berezutski, V. Berezutski, V. Berezutski, Ignashevich, Schennikov; Semberas, Aldonin; Krasic, Honda, Gonzalez; Necid.
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