Atletico Madrid have announced that winger Arda Turan and defender Antonio Lopez have both been ruled out of Saturday's La Liga match at Granada.
The Turkish star sustained a muscle injury while on international duty earlier in the week, while Antonio Lopez has picked up an adductor problem in training.
Atletico have not yet announced how long the injured duo will be sidelined, but have confirmed they will miss the trip to the relegation-threatened side.
Meanwhile, full-back Silvio is in doubt for Saturday's fixture due to a pubic bone injiury, which recently forced him to miss Portugal's last two Euro 2012 qualifiers.
Atletico sit eighth in the La Liga table, with eight points from six games.