The 27-year-old is no longer an undisputed starter at Barcelona following the arrival of Neymar and Luis Suarez in the past two years and has been heavily linked with a summer exit.
His buyout clause recently dropped from €150 million to €30m and clubs such as Chelsea and Manchester United are keeping a close eye on the versatile attacker's situation.
Luis Enrique stressed earlier this month that he is hopeful Pedro will stay put and he has now made it clear Barca will not allow the forward to leave on the cheap.
"Pedro? If he wants to go, a club will have to meet his release clause," Luis Enrique was quoted as saying by Sport.
"I have talked with Pedro to discuss his situation. I have told him how I think about it and he told me how he feels about it.
"I obviously won't reveal the exact content of the conversation we had."
Luis Enrique also had his say on the situation of Adriano - who has been heavily linked with a move to Roma - and stressed that, even though the Brazilian's situation is different to that of Pedro, he will not be granted an exit on the cheap, either.
"I have not talked with Adriano, because this are all rumours. Pedro's case is different.
"But I have already said before that we cannot prevent players from leaving if a club meets someone's exit clause."
The 30-year-old has a contract with Barcelona until June 2017.