Juventus have been rocked by the news that Claudio Marchisio will be out of action for another month through injury.
The Italy international had only just returned to action after missing the first two games of the new Serie A season with a hamstring problem.
Marchisio made his comeback in Saturday's clash with Chievo in Turin but lasted just 45 minutes, with subsequent scans revealing that the midfielder had suffered a grade 1-2 strain of his right adductor muscle.
The 29-year-old's injury issues have hit Juve hard, with the reigning Italian champions having only picked up a point from their first three league outings.
Marchisio had been the man charged with the responsibility of filling the void left by influential playmaker Andrea Pirlo, who departed for New York City FC during the summer.
With Marchisio now facing another spell on the sidelines, it is believed that Hernanes, a deadline-day arrival from Inter, could be asked to play as a regista, rather than the trequartista he was signed to be.
Indeed, it is thought that the Brazilian could start in front of the defence in Tuesday's Champions League showdown with Manchester City at the Etihad.
As well as the trip to Manchester, Marchisio is now also set to sit out the upcoming Serie A clashes with Genoa, Frosinone, Napoli and Bologna and the Champions League meeting with Sevilla at the end of the month.