The Mediterranean nation were narrowly defeated by Scotland on Saturday evening, although in their previous European championships qualifying campaign, Cyprus did win away games in Bosnia, Andorra and Israel.
888Sport price a victory for Russia at 7/25 (1.28) and the hosts will have plenty of confidence after high-scoring back-to-back wins against San Marino and Kazahkstan.
Dmitri Barinov could get his first international start after making his debut from the bench against San Marino. Artem Dzyuba is likely to once more lead the attack for Russia and the captain will be aiming to add to the five goals he has already scored in qualifying.
Cyprus have first-choice goalkeeper Konstantinos Panagi injured so Urko Pardo is likely to deputise as he did against Scotland.
While Cyprus should provide more of a test than San Marino, Russia should still be able to record a healthy victory.
The Cypriots have not kept a clean sheet in a competitive game away from home in 12 years, and against a rampant Russian outfit, the visitors could struggle once more.
Ran Ben Shimon's side are missing their first choice goalkeeper and their uninspiring defensive record on the road is likely to continue on Wednesday.
Tips and predictions
Russia are priced at 19/25 (1.76) to win with a -1 handicap and given their recent scoring record backing them to win by two goals against clearly inferior opposition makes plenty of sense.