After a difficult year featuring an embarrassing early World Cup exit followed by a last place finish in their Nations League group, Joachim Low's side have begun this campaign with two wins from two.
Unbeaten in 27 World and European qualification matches, they are overwhelming 1/40 (1.03) favourites with 888Sport to make it nine points from nine by coming out on top in this one.
Martin Reim's men have lost both of their Group C fixtures so far, and are massive 60/1 (61.00) outsiders to pull off a shock win here.
The hosts drew both of their Nations League fixtures on home soil, but are priced at 18/1 (19.00) to be held to stalemate yet again.
Toni Kroos, Antonio Rudiger and Marc-Andre ter Stegen were all unavailable for squad selection due to injury, while Ilkay Gundogan is a slight doubt following Saturday’s 2-0 win in Belarus.
The visitors remain without captain and key defender Ragnar Klavan as he struggles with an ankle issue, with Henri Anier and Dmitri Kruglov also ruled out.
Klavan’s absence is a major blow for a backline faced with the daunting task of containing a star-studded opposition attack that usually proves fruitful in front of their own fans.
Low’s men have only failed to score once in 27 competitive home matches, and averaged almost five goals per home game in their most recent qualification campaign.
All things considered, odds of 7/10 (1.70) seem like solid value on Germany scoring at least four times against their injury-struck Estonian guests.