Los Rojiblancos have failed to record a victory in their last 16 league meetings with the Catalans, with their last top flight success coming back in February 2010.
Barca meanwhile, come into the game off the back of 4-3 home defeat at the hands of Real Betis, and despite leading the La Liga table there have been plenty of questions asked of the Blaugrana in recent weeks.
Atletico have won 12 of their last 16 home league games and bet365 price them at 21/10 (3.10) to pick up another three points.
Barca needed two goals in the last three minutes to record a 3-2 win at Rayo Vallecano in their previous away game. They have also drawn 1-1 at Valencia and lost 2-1 at Leganes this season. As such, the Catalans are offered at 6/5 (2.20) with the draw available at 5/2 (3.50).
Watch and bet live on Atletico Madrid vs Barcelona
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Atletico Madrid will be without captain Diego Godin, who picked up an injury in their last game against Athletic Bilbao. The hosts could be boosted in defence by the return of Stefan Savic and Lucas Hernandez. Diego Costa should also return up front for Diego Simeone's side.
Barcelona could have Philippe Coutinho back after the Brazilian returned to training this week following an injury picked up against Inter Milan. Ivan Rakitic is suspended for the visitors after a red card against Betis last time out with Arturo Vidal or Sergi Roberto likely to replace him in midfield.
In terms of the title race this looks like being a key fixture, with Atleti just a point behind Barca at the top of the table and both teams will feel it is important to not lose this match.
Neither side have been firing on all cylinders recently and in this most competitive of La Liga seasons, the division's bigger side have been dropping points in the most unexpected of places.
In their respective matches prior to the international break, both sides were much more dangerous in the second half, and there are plenty of reasons for punters to invest in a cagey opening to this game.
Tips and predictions
This selection has paid out in each of Barca's last four league games and in four of Atletico's last five top flight clashes. Furthermore, the Estadio Wanda Metropolitano has seen 14 goals scored in La Liga this term, but only five of those goals have come in the first half.
Prices correct at the time of writing. Please gamble responsibly.