The 26-year-old has not appeared for the Three Lions since Euro 2016, but appeared to be in the running for a place on the plane to Russia.
However, a series of late-season knocks are said to have convinced manager Gareth Southgate to look elsewhere.
And Wilshere suggested he will be free over the off-season with his response to someone inviting him on a trip to Zante with "the lads".
Alongside two laughing emojis, he replied on Twitter: "Let me know the dates and I'm in."
let me know the dates and I'm in https://t.co/6PgPvhg77X— Jack Wilshere (@JackWilshere) May 16, 2018
Can i bring the baby aswell? https://t.co/fWLpEGZgB6— Jack Wilshere (@JackWilshere) May 16, 2018
Wilshere continued the light-hearted interaction by adding: "Can I bring the baby as well?"