Owing to a lack of competitive domestic action, Black Stars coach Maxwell Konadu has put faith in personnel of the Porcupine Warriors - who play in the Champions League - and the Miners - who feature in the Confederation Cup - to lead Ghana's quest for a third title.
Kotoko goalkeeper Felix Annan, a member of Ghana's squad at the Africa Cup of Nations (Afcon) in Egypt earlier this year, headlines the Kotoko contingent which also includes midfielder Justice Blay and striker Richard Arthur.
In-form AshGold frontman Mumuni Shafiu leads the club's party. Hearts of Oak's Mohammed Alhassan, who made Ghana's provisional squad for Afcon 2019, and teammates Fatawu Mohammed, Benjamin Afutu as well as Joseph Esso are also on the roster for Senegal.
The home-based Black Stars, the most successful team in the history of the tournament with two titles, were originally due to face Gambia in their opening game on Sunday but the match has been rescheduled for Tuesday.
The Wafu Cup will be contested by representative teams of the West African Football Union (Wafu).
Goalkeepers: Felix Annan, Eric Ofori Antwi, Isaac Hagan
Defenders: Fatawu Mohammed, Issaka Mohammed, Yussif Ouattara, Moro Ibrahim, Mohammed Alhassan, Patrick Yeboah, Habib Mohammed
Midfielders: Benjamin Afutu, James Akominko, Abdul Latif Anabila, Emmanuel Gyamfi, Augustine Okrah, Appiah McCarthy, Justice Blay
Strikers: Prince Opoku Agyemang, Joseph Esso, Richard Arthur, Shafiu Mununi