Both sides are embroiled in a tough battle to finish inside the top four, adding fuel to an already fiery fixture set to take place at the Etihad Stadium.
City and United have star quality on the pitch and also in the dugout, with Pep Guardiola and Jose Mourinho recognised as two of the game's greatest managers.
But who would win a fight between Pep and Jose? Who better to ask than Manchester lad and former WBA world lightweight boxing champion Anthony Crolla.
Check out the video above to hear who Crolla believes would get the better of the other if the managers were to trade blows!
Crolla was speaking as part of Betsafe's 'The Boots are Off' content ahead of the Manchester derby tomorrow.