A much-rotated side swept Wimbledon aside at Wembley, winning 3-0, to earn an away tie against lower-league Newport County.
The Toffees, meanwhile, came unstuck against Merseyside rivals Liverpool at Anfield - Virgil van Dijk's late header on his debut stealing the headlines - and are on the hunt for their first win in five games in all competitions.
Danny Rose has a knee injury and will miss the encounter, while Toby Alderweireld remains on the sidelines with a hamstring problem.
Spurs have no suspended players.
TOTTENHAM STARTING LINE-UP
Mauricio Pochettino made a number of changes to his XI for the encounter with Wimbledon, with Kieran Trippier and Kyle Walker-Peters involved as full-backs and Fernando Llorente starting up front.
Due to the Argentine's penchant for rotation, expect Ben Davies to return on the left of defence, while Serge Aurier could replace his English cohort at right-back.
Llorente is likely to return to the bench, allowing Harry Kane to lead the line on his own, while Christian Eriksen and Dele Alli should return after being rested last weekend.
EVERTON TEAM NEWS
Michael Keane is a doubt for Everton due to a foot injury, while Leighton Baines will definitely miss out due to a calf muscle strain.
Seamus Coleman is on the long-term injury list due to a broken leg, while Ramiro Funes Mori and Maarten Stekelenburg are also injured.
TV CHANNEL & KICK OFF TIME
The match takes place at 17:30 GMT (12:30 ET) on Saturday and will be shown live in the UK on BT Sport 1. Highlights can be caught on BBC's Match of the Day at 22:30 GMT.
BEST OPTA MATCH FACTS
Tottenham are unbeaten in their last 10 Premier League games against Everton (W5 D5), their longest such run against them since a run of 13 between 1997 and 2003.
Everton haven’t won away in the league at Spurs since November 2008 (1-0), drawing three and losing five since then.
Son Heung-Min could become just the second Spurs player to score in five consecutive home Premier League games after Jermain Defoe, who did so between November and December 2004.
Just 29.6% of Everton’s Premier League points this season have come away from home (8/27), the lowest ratio in the division.