The winger was handed a starting shirt by coach Gernot Rohr and featured for 45 minutes before he was substituted for Samuel Kalu.
The forward admitted at being caught by surprise after receiving his senior
"Making my debut for Nigeria only completes a dream year in my professional life," Chukwueze told BBC Sport.
"I've played and scored for Villarreal this year, and I never expected to get a chance to get into the Super Eagles team, but everything is happening like a dream.
"Some people wait for several years to live a dream but I am grateful to Villarreal and Nigeria for making all my dreams happen in under a year."
The forward who has been likened to Bayern Munich winger Arjen Robben is hoping to emulate his hero.
"My friends started the whole Arjen Robben comparison because of my playing style and I consider him as my first football hero," he added.
"I know there is still a lot for me to do to even come close to what he has achieved in football, so I am not getting carried away.
"I have some big players to look up to and I hope to continue my best to achieve more dreams with both Villarreal and Nigeria."
Chukwueze will hope to make his third La Liga appearance when Villarreal host Real Betis at Estadio de la Ceramica on Sunday.