The hosts took the lead just two minutes into the game and it was English hitman James Keene, who hit the back of the net.
It was soon 2-0 to Matsatsantsa and this time it was South Africa international Aubrey Modiba, who found the back of the net in the 34th minute.
Evans Rusike set-up Modiba and the latter beat the former Jomo Cosmos shot-stopper Ndlovu to make it 2-0 to SuperSport.
Lidoda Duvha tried to pull one back before the half-time break with Lesedi Kapinga leading their attack.
SuperSport managed to hold on to their lead and they were 2-0 up at the interval having dominated the first half.
Leopards head coach Joel Masutha introduced Lifa Hlongwane after the restart as the visitors looked to score their first goal of the match.
However, it was the hosts, who scored the next goal through Zimbabwean marksman Rusike in the 70th minute.
The hard-working striker netted his fourth league goal of the season to make it 3-0 to SuperSport much to the delight of the home crowd.
Rusike then turned provider as he set-up brace hero Keene, who sealed SuperSport's 4-0 win over Leopards with a good finish in the closing stages of the game.
The victory took Matsatsantsa to fifth place on the league standings, while Lidoda Duvha slipped down to 15th spot on the table.
It took only two minutes for the Team of Choice to take a surprise lead through promising central midfielder Bandile Shandu.
The 23-year-old player beat Celtic's Cameroonian goalkeeper Patrick Tignyemb to make it 1-0 to Maritzburg, who were searching for their first win of the season.
Phunya Sele Sele were keen to level matters before the half-time break with the reigning PSL Player of the Month for August Alfred Ndengane working tirelessly.
As a result, Celtic were trailing 1-0 against Maritzburg at half-time following a lively first half in the city of Roses.
A quiet second half followed as the Phunya Sele Sele and Team of Choice created chances which they failed to convert.
Ultimately, the game ended in a 1-0 victory in favour of Maritzburg, who managed to contain Celtic in the latter stages of the encounter.
The victory took the Team of Choice to 13th place on the league standings, while Phunya Sele Sele slipped down to fourth spot on the table.