Both clubs have collected six points out of six so far by defeating Borussia Dortmund and APOEL.
Madrid will be targeting a third win and one foot in the knockout stage at the Santiago Bernabeu but a point would go a long way towards helping Spurs achieve the same goal.
|Game||Real Madrid vs Tottenham|
|Date||Tuesday, October 17|
|Time||19:45 BST / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on BT Sport 2 or by stream via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
In the US, the match will be available to watch live on television on FS2 and by stream via Fox Sports Go.
|US TV channel||Online stream|
|FS2||Fox Sports Go|
SQUADS & TEAM NEWS
|Position||Real Madrid players|
|Defenders||Vallejo, Ramos, Varane, Nacho, Marcelo, Theo, Achraf|
|Midfielders||Kroos, Modric, Casemiro, Vazquez, Llorente, Asensio, Isco, Ceballos|
|Forwards||Ronaldo, Benzema, Mayoral|
Real Madrid are missing Gareth Bale, Dani Carvajal and Mateo Kovacic to injury or illness, while third-choice goalkeeper Luca Zidane worked out alone on Monday.
Youth goalkeeper Moha Ramos was on the bench at the weekend as a result of Luca and Keylor Navas' absences but the Costa Rican is expected to be ready to return for this match after a muscle problem.
Zidane will have to decide between 18-year-old Achraf Hakimi, who has started two games at right-back in Carvajal's absence, and the more experienced Nacho.
Potential starting XI: Navas; Nacho, Varane, Ramos, Marcelo; Modric, Casemiro, Kroos; Isco; Benzema, Ronaldo.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Alderweireld, Vertonghen, Sanchez, Foyth, Aurier, Davies, Walker-Peters|
|Midfielders||Nkoudou, Dier, Sissoko, Dembele, Eriksen, Winks|
|Forwards||Son, Kane, Llorente|
Victor Wanyama could be back in time to face Liverpool at the weekend but will miss out here, while Dele Alli remains suspended.
Danny Rose and Mousa Dembele have travelled but while the latter has some chance of being involved, the former has only recently returned to full training along with Erik Lamela and is short of match fitness.
Ben Davies is also a doubt due to illness and Georges-Kevin Nkoudou will be assessed after taking a knock to the head late in the win over Bournemouth on Saturday.
Potential starting XI: Lloris; Sanchez, Alderweireld, Vertonghen; Aurier, Sissoko, Dier, Trippier; Eriksen, Kane, Son.
BETTING & MATCH ODDS
Madrid are 4/9 favourites to win, according to dabblebet, with Tottenham priced at 11/2 and the draw available at 15/4.
Whisper it quietly, but Tottenham have won eight out of 11 games this season and been defeated only once.
The strength of Spurs' record so far has been lost amid some unconvincing performances at Wembley, the latest of which resulted in a narrow 1-0 win over Bournemouth at the weekend.
Swansea City and Burnley have held Mauricio Pochettino's men to draws on their new turf and Chelsea beat them, though that was one of Tottenham's more impressive displays of the season and deserved a better outcome.
But Spurs are swatting teams aside away from home and have made an excellent start in the Champions League, leaving them third in the Premier League table and in with a good chance of reaching the European knockouts.
But if Pochettino can continue to guide his team through this unsteady period at Wembley without too much damage being done, another promising season could be in store ahead of the return to White Hart Lane.