Karim Benzema, Gareth Bale and Cristiano Ronaldo last lined up in the same starting XI in April's Clasico meeting with Barcelona.
Since then 279 days have passed, with the trio unable to function together due to injury problems for Bale and Benzema at various points of the 2017-18 season.
The BBC was reunited last week, however, when Benzema came on towards the end of Madrid's 7-1 thrashing of Deportivo, and now play from the off at Mestalla against the high-flying Che.
The Merengue are indeed at near full-strength, with Sergio Ramos the only notable absentee from Zinedine Zidane's favoured line-up as Nacho deputises at centre-back.
Valencia: Neto; Montoya, Coquelin, Garay, Lato; Guedes, Parejo, Kondogbia, Gaya; Rodrigo, Mina.
Substitutes: Jaume, Maksimovic, Vidal, Andreas, Soler, Vietto, Zaza.
Real Madrid: Navas; Carvajal, Nacho, Varane, Marcelo; Modric, Casemiro, Kroos; Bale, Benzema, Ronaldo.
Substitutes: Casilla, Llorente, Theo, Vazquez, Asensio, Mayoral, Kovacic.