Neither team is in particularly inspiring form heading into the business end of the season, with Betis having won just two of their last seven matches and La Real winning two of their last 11.
Imanol Alguacil's men have managed just four victories from the 14 matches they have played in front of their own fans this season. The Basques are priced at 23/20 (2.15) with William Hill to claim three points, while Betis can be backed at 12/5 (3.40) to claim their sixth away win of the season.
The draw meanwhile is available at 12/5 (3.40) and four of the last five meetings in all competitions between these two sides have ended as stalemates.
The visitors have concerns over both first-choice wing-backs with Francis Guerrero almost certainly out, and Junior Firpo only just returning to training after missing the last eight games.
La Real are missing influential midfielder Asier Illarramendi, while Adnan Januzaj is also a doubt. Mikel Merino will come back into the side for the hosts in midfield having been suspended for the weekend draw at Valladolid.
Real Betis are fractionally behind leaders Barcelona in terms of average percentage possesion per game, yet when it comes to goals scored 10 sides have netted more than Los Verdiblancos.
On the road Quique Setien's side have managed just 14 strikes in as many games, and they were fortunate to score from a deflected shot on Sunday at struggling Rayo Vallecano.
La Real have failed to score in six of their last 12 home league matches and neither of these sides have seen a host of high-scoring games this term. Betis' matches have seen on average 2.41 goals, with Sociedad's at 2.34 and opposing goals when two out-of-form sides meet makes sense.
Tips and predictions
Under 2.5 goals is priced at 4/6 (1.66) which gives an indication that a low-scoring game is expected.
Combining this selection with both teams to score 'no', essentially meaning one team must keep a clean sheet offers more appealing odds of 11/10 (2.10).
This bet has paid out in three of the last four competitive meetings between these teams and looks attractively priced once more.