Cavani converted Adrien Rabiot's cross in the 11th minute - his 157th strike for the Ligue 1 giants - to set a new benchmark.
Cavani was presented with a trophy after the game in front of a giant and lit-up '157' by president Nasser Al-Khelaifi.
Cavani threw his shirt into the crowd in celebrating his goal, giving a lucky home fan a souvenir, and the striker expressed his delight to be woven into the fabric of PSG.
"It's something magnificent, I'm very emotional," Cavani told Canal+.
"In life, you're not always given so much warmth. I'm very content, very happy to be here."