The 2014 world champions drew with France in their opening match in the tournament 0-0, and having seen the French then record a win over the Dutch, Joachim Low's side know they need three points from their trip to Amsterdam.
This is one of the oldest rivalries in European football and Germany are unbeaten in this fixture since 2002, winning two and drawn three of the last five meetings, and bet365 offer the visitors at evens (2.00).
The hosts can be backed at 13/5 (3.60) and the Dutch have won five of their last six home matches in all competitions.
With Kevin Trapp and Leon Goretzka withdrawing from the German squad, Joachim Low has called up Bernd Leno and Serge Gnabry as cover. Marco Reus and Antonio Rudiger are also missing through injury.
Netherlands are missing Brighton midfielder Davy Propper after he pulled out of the squad through injury. Coach Ronald Koeman has opted not to call up a replacement.
The Dutch national team may be going through a transitional process but they can still be relied upon to find the back of the net.
Germany, for their part, are still rebuilding after their disappointment in Russia this summer and the four-time World Cup winners have kept just one clean sheet in the nine matches they have played in 2018.
Therefore, Netherlands will fancy their chances of scoring, yet but they do remain vulnerable at the back with just one clean sheet in their last six games.
Tips and predictions
This selection has paid out in four of Germany's last seven matches as well as in both of Netherlands most recent encounters.
Prices correct at the time of writing. Please gamble responsibly.