The Red Devils are unbeaten in their last five games in all competitions, picking up four wins, and they come into the clash against Ronald Koeman's side on the back of a 3-0 Champions League victory over Basel.
While United are winning games and full of confidence, Everton are languishing at the bottom end of the table. The Toffees have failed to secure a win in their last five games in all competitions and make the trip to Old Trafford with a three-game losing streak hanging over their heads.
|Game||Manchester United vs Everton|
|Date||Sunday, September 17|
|Time||16:00 BST / 11:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports Premier League as well as being available to stream online via the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
In the US, viewers can watch live on television on NBCSN, or else they can stream the game live online through the NBC Sports app.
|US TV channel||Online stream|
|NBCSN||NBC Sports app|
SQUADS & TEAM NEWS
|Position||Manchester United players|
|Goalkeepers||De Gea, Romero, J. Pereira|
|Defenders||Lindelof, Bailly, Jones, Rojo, Smalling, Blind, Shaw, Valencia, Darmian, Tuanzebe|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Herrera, Mkhitaryan, Fellaini, Matic, McTominay|
|Forwards||Lukaku, Ibrahimovic, Martial, Wilson, Rashford|
Paul Pogba is expected to miss out after suffering an injury in the Champions League against Basel, meaning Marouane Fellaini could take his place in midfield.
Eric Bailly and Phil Jones missed the game against Basel due to suspension, but should return to the starting XI in place of Chris Smalling and Victor Lindelof.
Potential starting XI: De Gea; Valencia, Bailly, Jones, Darmian; Fellaini, Matic, Herrera, Mkhitaryan; Rashford, Lukaku.
|Goalkeepers||Pickford, Stekelenburg, Robles|
|Defenders||Baines, Keane, Williams, Jagielka, Martina, Coleman, Funes Mori, Holgate, Kenny|
|Midfielders||Schneiderlin, Barkley, Lennon, McCarthy, Gueye, Sigurdsson, Klaassen, Besic, Davies|
|Forwards||Bolasie, Ramirez, Rooney, Mirallas, Vlasic, Calvert-Lewin, Lookman, Niasse|
Everton will be without a host of players due to injury, with Ross Barkley, Yannick Bolasie, Seamus Coleman, James McCarthy and Ramiro Funes Mori all sidelined.
Potential starting XI: Pickford; Baines, Keane, Williams, Jagielka; Schneiderlin, Gueye, Sigurdsson, Davies; Rooney, Ramirez.
BETTING & MATCH ODDS
At 2/5, Manchester United are favourites to win according to dabblebet, with Everton priced at 7/1 to win at Old Trafford. A draw is available at 15/4.
Jose Mourinho has continued to build on the foundations he laid during his first season at the helm of Manchester United and the Portuguese can be pleased his players have responded as they look down on their rivals from the summit of the Premier League.
Leaving aside the Super Cup defeat to Real Madrid at the beginning of the season, a 2-2 draw against a determined Stoke City is the only mark against United this term and Mourinho's reaction to that result shows exactly how high the standards have been set after the disappointment of finishing sixth last year.
With a floundering Everton next on their agenda, the high-flying Red Devils are considered strong favourites to win, but they will have to be wary as Koeman's side attempt to recover from back-to-back 3-0 defeats.
The game, of course, has the added narrative of two players facing their former clubs as Wayne Rooney returns to Old Trafford for the first time since ending his 13-year spell at United earlier this summer, while Romelu Lukaku looks to get the better of his erstwhile team-mates following his big-money move away from Goodison Park.