In the four games following the first leg, Sevilla have lost two and won two, showing grave inconsistencies in their performances.
It is no surprise to see Manchester United as favourites at 6/10 (1.60) given the only team they have lost to at Old Trafford in over two years are their city rivals who are currently market leaders for this competition.
Paul Pogba remains a huge injury doubt after he failed a late fitness test ahead of the Liverpool game, while Marouane Fellaini appears to be coming back to full match fitness and could replace Scott McTominay in the starting line-up.
Eric Bailly made his first start since November and will be expected to lead United’s defence to safety once again in this crucial tie. Anthony Martial is another doubt for the game and might miss his third match in a row, joining the likes of Ander Herrera, Marcos Rojo, Phil Jones and Daley Blind on the sidelines.
Vincenzo Montella’s team have already confirmed that Jesus Navas will not be travelling to Manchester due to injury.
Gabriel Mercado is expected to cover the former Manchester City player’s position at right back, meaning Simon Kjaer will fill in at centre-back. It will be a makeshift defence that could find it uneasy at Old Trafford.
A home win beckons
Manchester United seldom draw or lose at Old Trafford and have won their previous four games at home, including high pressure encounters against Chelsea and Liverpool.
The Red Devils have dropped points on only three occasion this season at this venue, with Mourinho turning the Theatre of Dreams back into a fortress that was the foundation of Sir Alex Ferguson’s success.
A home win and over 1.5 goals, offered at 19/20 (1.95), looks a safe bet given it has won in United’s last five matches at Old Trafford as well as 14 times over the course of the season.
Preview and predictions
However, the best bet is Manchester United to win and both teams to score, priced at 13/5 (3.60) with dabblebet.
Montella’s men have scored in nine of their last 10 matches away from home. Coupling that with United’s last two home games ending in 2-1 wins, this bet looks very favourable. That correct score is currently 15/2 (8.50) for those seeking an even bigger price.
Mourinho has a vast amount of experience, especially in Europe, and should be able to overcome the Spanish side with the abundance of quality he has at his disposal.