Paul Pogba has returned to the Manchester United XI, starting against Newcastle on Saturday for his first appearance since September.
Pogba and Ibrahimovic are not the only United players making an injury comeback on Saturday, though, with Marcus Rojo included in the squad for the first time since suffering a cruciate ligament injury in the same game as the Swedish striker.
Elsewhere, with Phil Jones injured on England duty, summer signing Victor Lindelof has been drafted into the United XI for his first Premier League start.
To make room for the injury returns, Henrikh Mkhitaryan has been dropped from the matchday squad.
Manchester United XI: De Gea, Valencia, Lindelof, Smalling, Young, Matic, Pogba, Mata, Rashford, Martial, Lukaku
Subs: Romero, Rojo, Shaw, Fellaini, Herrera, Lingard, Ibrahimovic
Newcastle XI: Elliot; Yedlin, Clark, Lejeune, Manquillo; Ritchie, Hayden, Shelvey, Murphy; Gayle, Joselu
Subs: Darlow, Gamez, Mbemba, Diame, Aarons, Perez