Already eight points clear at the top of the Premier League table, Pep Guardiola's side travel to the King Power Stadium in blistering form, with some even predicting they could go the season unbeaten.
Leicester, meanwhile, have shown improvements since Claude Puel replaced Craig Shakespeare last month, and have given a number of the top-six sides a run for their money already this campaign.
And after crushing City in the same fixture last season, they will be confident of causing an upset.
MAN CITY INJURIES
Benjamin Mendy remains out with an ACL injury, but Vincent Kompany may well return to the matchday squad having recovered from his most recent calf problem.
MAN CITY SUSPENSIONS
Nicolas Otamendi misses out having picked up his fifth booking of the season against Arsenal, but Leicester have no disciplinary issues to contend with.
MAN CITY POTENTIAL STARTING LINE-UP
Aguero's illness may mean he is forced into a place among the substitutes, with Sterling and Leroy Sane flanking Gabriel Jesus up front.
With Kompany still working his way back to fitness, Eliaquim Mangala could partner John Stones in central defence for his first Premier League start of the season.
LEICESTER CITY TEAM NEWS
Having missed out against Stoke City, full-back Ben Chilwell was forced to withdraw from the England Under-21 squad through injury and is a doubt for Claude Puel's third match in charge.
Robert Huth and Matty James remain on the sidelines, but the Foxes are hopeful they will have an otherwise clean bill of health as their players return from the international break.
OPTA MATCH FACTS
- Leicester have won two of their last three Premier League meetings with Manchester City (L1), including a 4-2 win in this exact fixture last campaign, in which Jamie Vardy scored to date his only Premier League hat-trick.
- The Foxes have lost their last eight Premier League games against sides who started the day top of the table, conceding at least two goals each time. Their last win against the league leaders came in January 1998 versus Manchester United at Old Trafford.
- Man City’s haul of 31 points with a goal difference of +31 is the best ever start after 11 games to a Premier League season. The Citizens themselves are the only side in Premier League history to have recorded 34 points from 12 games, doing so in 2011-12.
- Manchester City boast the two leading players for combined goals and assists this season – Sergio Aguero (8 goals, 3 assists) and Leroy Sane (6 goals, 5 assists). They also have the top two assisters in the division (David Silva 7, Kevin De Bruyne 6).
- Man City are bidding to become only the second team to win their first six away games to a PremierLeague campaign, after Chelsea in 2008-09 (won their first eight).
TV COVERAGE & KICK-OFF TIME
Kick off is 15:00 GMT with the game not being shown live in the UK. Highlights will be shown on Match of the Day on BBC One at 22:20.