City's European dreams are over for a season but they are in the FA Cup semi-finals and will be looking to consolidate their place in the top four.
MAN CITY INJURIES
Pep Guardiola picked close to his strongest team in midweek and will have to call on many of the same players again, which could be an issue given Liverpool last played on Sunday.
Vincent Kompany is fit but his role in Guardiola's plans is unknown and he will almost certainly not start, though he could be on the bench.
Gabriel Jesus and Ilkay Gundogan are still out injured.
MAN CITY SUSPENSIONS
Neither City nor Liverpool have any suspensions.
MAN CITY POTENTIAL STARTING LINE-UP
Yaya Toure is a contender to come back into the side, possibly for Kevin De Bruyne, who has looked tired of late, though Guardiola elected to keep the Ivorian out of the fast-paced game against Monaco and may decide the same course of action is needed against Liverpool.
The team as a whole will be largely unchanged. Pablo Zabaleta may come in at right-back, and Guardiola may as ever make a change in the centre of defence, but he will want to win this game and pick a strong as team as possible in City's last game before the international break.
LIVERPOOL TEAM NEWS
Jordan Henderson is out with a foot inury and Daniel Sturridge will miss the game with a hip complaint.
Dejan Lovren played 75 minutes for the U23s on Monday and Roberto Firmino is back in training but if he does not start then Divock Origi will line up at the head of the attack.
Ragnar Klavan and Joel Matip could continue at centre-back if Lovren does not make it, while Emre Can will sit at the base of midfield, alongside Gini Wijnaldum and Adam Lallana, with Henderson out.
Jurgen Klopp's side have been inconsistent this season and have generally been in poor form since the turn of the year, but have played at their best against their top four rivals.
BEST OPTA MATCH FACTS
Manchester City have lost five of their last six Premier League meetings with Liverpool (W1).
Indeed, Liverpool have won four consecutive league games against Man City for the first time since 1981 (a run of seven).
Manchester City have failed to keep a clean sheet in each of their last 12 games in all competitions against Liverpool, shipping 23 in the process (W2 D4 L6).
Man City’s next Premier League home win will be their 200th in the competition, becoming the eighth team to reach this milestone. 158 of those 199 wins have come at the Etihad, 41 at Maine Road.
Sergio Aguero has found the back of the net in all four of his Premier League games versus Liverpool at the Etihad Stadium (four goals).
TV COVERAGE & KICK-OFF TIME
The game kicks off at 19:45 UK time on Wednesday, February 1, and is available on BT Sport 1 in the UK.