Jurgen Klopp’s men ran out 4-3 winners when the sides met at Anfield in the league, having been thrashed 5-0 in the away match at the Etihad Stadium.
With a difficult second leg therefore still to come, they are available at 9/5 (2.80) with dabblebet to take an aggregate lead by coming out on top in front of their own fans.
The Citizens have won none and lost 11 of their last 16 visits to this ground, but are 11/8 (2.38) favourites to take control of the tie with a first victory here since 2003.
Two of the hosts’ four home matches in this season’s competition have resulted in draws, and you can get odds of 12/5 (3.40) on them playing out another stalemate in this one.
Adam Lallana has joined Joe Gomez on the sidelines after suffering a hamstring injury against Crystal Palace at the weekend, while Emre Can is a doubt with a back problem.
Joel Matip is set to undergo thigh surgery and will likely miss the rest of the season, meaning Dejan Lovren should start alongside Virgil van Dijk.
Sergio Aguero has been ruled out by Pep Guardiola with a knee injury, therefore Gabriel Jesus will get the nod again.
Aymeric Laporte should be in contention despite injuring his foot against Everton, while John Stones and Fabian Delph are also hoping to be fit.
Although perhaps not as glamorous as being paired with one of the continent’s superpowers, this draw should guarantee two thoroughly entertaining matches.
Indeed, these two domestic rivals have already produced 12 goals in two league encounters this season and are the Premier League's two top scorers
This free-scoring form has not been restricted to the league, with the Reds having scored 28 goals in their eight Champions League fixtures so far – more than any other team.
Guardiola’s team have scored four goals in three of their four away games in this competition, making odds of 6/4 (2.50) seem like solid value on them helping to ensure over 3.5 strikes here.