Frenchman Pierre Lechantre has fielded a strong starting line-up to face Njombe Mji away in the Ligi Kuu match held at Samora Stadium.
Ugandans, Juuko Murshid and Emmanuel Okwi both start while Haruna Niyonzima could return in action from the bench as Jonas Mkude is left out of the squad.
Simba who lead the table with 46 points will be keen to get a victory in order to ease pressure as their arch rivals Yanga are only behind them on goal difference.
After this game, Simba will travel to Morogoro to face Mtibwa Sugar on April 9 before returning to Iringa to face Lipuli on April 20.
Njombe Mji who are among the three bottom clubs, will be keen for a victory in order to avoid the drop.
Aishi Manula, Nicholas Gyan, Asante Kwasi, Juuko Murshid, Yusuph Mlipili, Erasto Nyoni, James Kotei, Shomari Kapombe, Emmanuel Okwi, John Bocco, Shiza Kichuya
Said Mohamed, Laudit Mavugo, Salim Mbonde, Haruna Niyonzima, Mohamed Hussein, Mzamiru Yassin Said Ndemla