On Tuesday, the holders face Juventus in a repeat of last season's final in Cardiff. Los Blancos won 4-1 on that occasion - a bet that's available at 40/1 (41.0) for the first leg of this quarter final clash against the Serie A champions at the Allianz Stadium.
Latest match odds
Juve have always been the outsiders for this game but have now drifted to 11/5 (3.20) to take a first leg advantage to the Bernabeu. The draw trades at 9/4 (3.25) while Real Madrid are favourites at 7/5 (2.40).
A history of open games
While Max Allegri's side are famed for their defensive steel, matches against Madrid are often pretty open affairs. Both teams have scored in the previous five head-to-head Champions League meetings and 41/50 (1.81) on a repeat this time around is tempting.
Ronaldo to shine once more
There's a better bet to be had with 888Sport, though. The online firm are going 11/8 (2.38) on Cristiano Ronaldo scoring at anytime in this first leg encounter.
Not only is Ronaldo the competition's all-time leading marksman with 117 goals in 148 games, but he has shown no signs of slowing down this term.
The Portugal international has already struck 12 times in the current European campaign and looks well set for another top scorer award regardless of Real Madrid's progression, boasting a four-goal advantage over his nearest rival.
Not only is the 33-year-old averaging a Champions League goal every 60 minutes of play this season but he also has an excellent record against Juventus.
Ronaldo has scored a total of seven times in the last five head-to-head meetings including at least one in every game. At 11/8 (2.38) he is surely a great goalscorer option against a Juventus side that he has enjoyed such success against in recent years.
Those hunting for a bigger price might also consider the 7/2 (4.50) on Ronaldo to score first, given that he has broken the deadlock in three of the previous clashes between these European heavyweights.
Odds correct at the time of publish